However, because of the sensitivity of a baby's skin, it should be taken with caution. Hydrocortisone is commonly used to reduce inflammation. If zinc oxide treatments are ineffective, creams that contain this component may be the best option. Hydrocortisone: Hydrocortisone is well-known for efficiently removing the rash and redness produced by a wide range of issues.Zinc oxide creams are a fantastic choice to try initially before moving on to brands with a different active ingredient because of their low cost and effectiveness. Creams that contain this component are typically simple to apply and cost less than other creams. It may be the best option for the usual diaper rash, but it may not be powerful enough for more serious cases. Zinc oxide: One of the most common chemicals in diaper rash lotion is zinc oxide.Antifungal lotions are commonly prescribed for diaper rash caused by yeast. Most over-the-counter lotions are usually effective for diaper rash, but if the rash persists, a doctor may need to prescribe a stronger cream or prescription medications. Zinc oxide, hydrocortisone, lanolin, and petroleum jelly are all common active components in diaper rash cream. Diaper rash cream has a variety of chemicals that make it effective, and not all creams have the same contents. Choosing the most effective cream for diaper rash usually entails diagnosing the cause of the rash and then experimenting with various solutions to discover which one works best.